Professor of shanghai Institute of Materia Medica, Chinese Academy of Sciences

The major research field of Prof. Yang’s group covers antibacterial agent, antidiabetic drug and antithrombotic drug discovery, new method and new process for drug synthesis, and the group has rich experience in innovative drug research. In 2009, the first new fluoroquinolone antibacterial agent with independent intellectual property―antofloxacin hydrochloride was successfully developed by Yang’s group. It is recognized as the landmark achievement of the “Key New Drug Creation and Manufacturing Program” of the “Eleventh Five-year Plan” in China, filling up the innovation gap in this field in more than 40 years. Antofloxacin hydrochloride has a better safety profile and pharmacokinetic property and its successful marketing is of great importance to the promotion of national innovative drug research and self-innovative ability in China.

Prof. Yang won the 2013 China Pharmacy Development Award-Innovative Drugs Award-Outstanding Achievement Award. In 2010, he won the title of “2007-2009 Advanced Worker in Shanghai (Model Worker)”. In 2010, he won the IBC China Drug Discovery of the Year Award.

Academician of Chinese Academy of Engineering

The Fen-er Chen Group Honors

1、Chinese Chemical Society-Sci Finder Award for Creative Work in Synthetic Organic Chemistry in 2011

2、National excellent scientific and technological workers in 2010

3、ten elites of science and technology in Shanghai in 2009

4、Second prize of Shanghai invention patents in 2008

5、Second prize of National Science and Technology Progress Award in 2007

6、Prize for scientific and technological progress in medical sciences and materia medica in Ho Leung Ho Lee Foundation in 2006

7、The invention of Chinese entrepreneurship Award in 2006

8、Award for outstanding Chinese patented invention in world intellectual property organization in 2006

9、ten staffs of excellence and innovation in Shanghai in 2006

10、Shanghai inventor Award in 2006

11、Wu Yunchu Award for chemical talents incentive fund in 2005

12、Second prize of national technological invention Award in 2005

13、Award for outstanding Chinese patented invention in world intellectual property organization in 2005

14、First Prize for Ministry of Education Science and Technology Progress Award in 2004

15、First prize for invention patent IN Shanghai in 2004

16、China Pharmacy Development Award Outstanding Young Scholar Award in 2004

17、First prize for scientific and technological progress in Shanghai in 2003

18、Special government allowances of the State Council in 1993

Professor of Sun Yat-sen University

Representative papers

1. Dan Zhang, Jun Zhou, Fei Xia, Zhenghui Kang, and Wenhao Hu*, Bond cleavage, fragment modification and reassembly in enantioselective three-component reactions, Nat Commun. 2015, 6, 5801.

2. Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu,* Fei Xia, and Wenhao Hu*, An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three-Component Reaction through Trapping of Rhodium(I)-Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed. 2014, 53, 13136-13139.

3. Dan Zhang, Huang Qiu, Liqin Jiang,* Fengping Lv, Chaoqun Ma, and Wenhao Hu*,. Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines. Angew. Chem. Int. Ed. 2013, 125, 13598-13602.

4. Shikun Jia, Dong Xing, Dan Zhang, and Wenhao Hu*, Catalytic Asymmetric Functionalization of Aromatic C-H Bonds by Electrophilic Trapping of Metal-Carbene-Induced Zwitterionic Intermediates, Angew. Chem. Int. Ed. 2014, 53, 13098-13101.

5. Changcheng Jing, Dong Xing, Yu Qian, Taoda Shi, Yun Zhao, and Wenhao Hu*, Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates. Angew. Chem. Int. Ed. 2013, 52, 9289-9292.

6. Xin Guo, and Wenhao Hu*, Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles, Acc. Chem. Res. 2013, 46, 2427-2440.

7. Jun Jiang, Xiaoyu Guan, Shunying Liu, Baiyan Ren, Xiaochu Ma, Xin Guo, Fengping Lv, Xiang Wu, and Wenhao Hu*, Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols, Angew. Chem. Int. Ed. 2013, 52, 1539-1542.

8. Huang Qiu, Ming Li, Li-Qin Jiang, Feng-Ping Lv, Li Zan, Chang-Wei Zhai, Michael P. Doyle, and Wen-Hao Hu*, Highly enantioselective trapping of zwitterionic intermediates by imines, Nature Chem. 2012, 4, 733-739.

9. Jun Jiang, Hua-Dong Xu, Jian-Bei Xi, Bai-Yan Ren, Feng-Ping Lv, Xin Guo, Li-Qin Jiang, Zhi-Yong Zhang, and Wenhao Hu*, Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines, J. Am. Chem. Soc. 2011, 133, 8428-8431.

10. Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Cooperative Catalysis in Multicomponent Reactions: Highly Enantioselective Synthesis of γ-Hydroxyketones with a Quaternary Carbon Stereocenter, Angew. Chem. Int. Ed. 2010, 49, 2190-2192.